What is the role of the HER2/ERBB2 receptor in breast cells?

The HER2/ERBB2 receptor serves as a protein that functions as a receptor on the surface of breast cells. This receptor is part of the human epidermal growth factor receptor (HER) family and plays a crucial role in cellular signaling. When growth factors bind to the HER2 receptor, it activates signaling pathways that promote cell proliferation and survival, influencing the growth and division of breast cells.

Understanding this role is essential in the context of breast cancer, as overexpression of the HER2 protein is associated with aggressive forms of the disease. Therapeutic strategies targeting the HER2 receptor, such as monoclonal antibodies, can be effective in treating HER2-positive breast cancer. This highlights the importance of understanding the specific functions of receptors like HER2 in the management and treatment of breast cancer.